North Duplin battled hard for four quarters, but the Rebels fell to Northside-Pinetown, 49-6, at H.E. Grubbs Field on Friday evening.
The Rebels were down 7-6 after the first quarter, but the Panthers outscored the Rebels 42-0 during the final three quarters to win the game.
Dujuan Armwood rushed for a team-high 30 yards on 12 carries, while Luis Olivos collected 11 yards on seven carries.
North Duplin (0-2 overall) entertains Jones (0-1) next Friday.